Get Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in PDF

By Falk Nimmerjahn

Autoimmune issues are characterised by way of the destruction of self-tissues by means of the immune method. a number of checkpoints are in position to avoid autoreactivity less than basic conditions. Co-expression of activating and inhibitory Fc receptors (FcRs) represents any such checkpoint through constructing a threshold for immune mobilephone activation. in lots of human autoimmune ailments, although, balanced FcR expression is disturbed. research of murine version structures offers robust proof that aberrant FcR expression can lead to out of control immune responses and the initiation of autoimmune illness. This evaluate summarizes those facts and explains how this knowledge may be used to higher comprehend human autoimmune ailments and to improve novel healing strategies.

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Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in Autoimmune Disorders by Falk Nimmerjahn

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